Lipodistrofia generalizada congênita: correlação com leptina e outros aspectos bioquímicos / Generalized congenital lipodystrophy: correlation with leptin and other biochemical parameters
Acta cir. bras
; 20(supl.1): 190-195, 2005.
Article
in Pt
| LILACS
| ID: lil-474166
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To correlate serum leptin and insulin levels, and the glucosic profile of 21 patients shared in diabetics and non diabetics with Congenital Generalized Lipodystrophy (CGL).METHODS:
In a prospective study, were dosed serum leptin level with radioimmunoassay technique, fasting plasma glucose through of the glucoseoxidase-peroxidase reaction, the hemoglobin glycate using the technique microchromatography for ionic exchange resin and insulin through immunoassay system. The fructosamine concentration serum was determinated for reduction nitroblue tetrazolium method. The Student's test was used to compare results between the groups and the correlation [quot ]r[quot ] coefficient to analise the relation among the several variants studied, with significant level of 5% (p < 0.05). All the statistical procedures were performed using the Excel by Microsoft and the Statistic program for Windows by StatSoft, Inc. version 5.1 edition 97.RESULTS:
Leptin decreased on the most patients, showing no statistically significant difference between the groups. Also there wasn't difference statistically significant (p = 0.9542) of the insulin's value between diabetics and non diabetics.CONCLUSION:
The hyperinsulinism and the hypoleptinemia occurred independently of diabetes in the CGL's patients and this can be due to the natural history of disease, in which the raise insulin levels precede the initial diabetes mellitus and the low leptin levels were related to the lipoatrophy.
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Index:
LILACS
Main subject:
Adipose Tissue
/
Leptin
/
Diabetes Mellitus, Lipoatrophic
/
Lipodystrophy, Congenital Generalized
/
Hyperinsulinism
Type of study:
Observational_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Pt
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2005
Type:
Article