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Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
Souza, Claudio Lima; Barbosa, Cynara Gomes; Moura Neto, José Pereira de; Barreto, José Henrique; Reis, Mitermayer Galvão; Gonçalves, Marilda Souza.
Affiliation
  • Souza, Claudio Lima; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Barbosa, Cynara Gomes; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Moura Neto, José Pereira de; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Barreto, José Henrique; Clínica Onco. Salvador. BR
  • Reis, Mitermayer Galvão; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Gonçalves, Marilda Souza; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
Genet. mol. biol ; 31(1): 39-41, 2008. tab
Article in En | LILACS | ID: lil-476148
Responsible library: BR26.1
ABSTRACT
The null genotype for glutathione S-transferase (GST, EC 2.5.1.18) gene polymorphisms is considered a risk factor for leukemia in different populations. In this work we investigated the GSTT1 and GSTM1 polymorphisms using multiplex PCR in 53 patients with chronic myeloid leukemia (CML), 23 with acute promyelocytic leukemia (APL) and 304 apparently healthy controls. In this association study we found that the GSTT1null genotype was more frequent in our group of APL patients than in the control group [OR = 2.75 (95 percent CI = 1.10-6.88)], providing evidence that a deletion in the GSTT1 gene could be a risk factor for this type of leukemia.
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Full text: 1 Index: LILACS Main subject: Leukemia, Promyelocytic, Acute / Leukemia, Myeloid / Glutathione Transferase Type of study: Etiology_studies Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Genet. mol. biol Journal subject: GENETICA Year: 2008 Type: Article
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Full text: 1 Index: LILACS Main subject: Leukemia, Promyelocytic, Acute / Leukemia, Myeloid / Glutathione Transferase Type of study: Etiology_studies Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Genet. mol. biol Journal subject: GENETICA Year: 2008 Type: Article