Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies
Mem. Inst. Oswaldo Cruz
;
104(6): 862-864, Sept. 2009. ilus
Article
in English
| LILACS
| ID: lil-529555
ABSTRACT
The primary culture of intestinal epithelial cells from domestic cats is an efficient cellular model to study the enteric cycle of Toxoplasma gondii in a definitive host. The parasite-host cell ratio can be pointed out as a decisive factor that determines the intracellular fate of bradyzoites forms. The development of the syncytial-like forms of T. gondii was observed using the 120 bradyzoite-host cell ratio, resulting in similar forms described in in vivo systems. This alternative study potentially opens up the field for investigation into the molecular aspects of this interaction. This can contribute to the development of new strategies for intervention of a main route by which toxoplasmosis spreads.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Toxoplasma
/
Epithelial Cells
/
Host-Parasite Interactions
/
Intestinal Mucosa
/
Life Cycle Stages
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Oswaldo Cruz-Fiocruz/BR
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