Experience with different botulinum toxins for the treatment of refractory neurogenic detrusor overactivity
Int. braz. j. urol
; 36(1): 66-74, Jan.-Feb. 2010. graf, tab
Article
in En
| LILACS
| ID: lil-544077
Responsible library:
BR1.1
ABSTRACT
Purpose:
To report our experience with the use of the botulinum toxin-A (BoNT/A) formulations Botox® and Prosigne® in the treatment of neurogenic detrusor overactivity (NDO). Materials andmethods:
At a single institution, 45 consecutive patients with refractory urinary incontinence due to NDO received a single intradetrusor (excluding the trigone) treatment with botulinum toxin type A 200 or 300 units. Botox was used for the first 22 patients, and Prosigne for the subsequent 23 patients. Evaluations at baseline and week 12 included assessment of continence and urodynamics. Safety evaluations included monitoring of vital signs, hematuria during the procedure, hospital stay, and spontaneous adverse event reports.Results:
A total of 42 patients were evaluated (74 percent male; mean age, 34.8 years). Significant improvements from baseline in maximum cystometric capacity (MCC), maximum detrusor pressure during bladder contraction, and compliance were observed in both groups (P < 0.05). Improvement in MCC was significantly greater with Botox versus Prosigne (+103.3 percent vs. +42.2 percent; P = 0.019). Continence was achieved by week 12 in 16 Botox recipients (76.2 percent) and 10 Prosigne recipients (47.6 percent; P = 0.057). No severe adverse events were observed. Mild adverse events included 2 cases of transient hematuria on the first postoperative day (no specific treatment required), and 3 cases of afebrile urinary tract infection.Conclusions:
Botox and Prosigne produce distinct effects in patients with NDO, with a greater increase in MCC with Botox. Further evaluation will be required to assess differences between these formulations.Key words
Full text:
1
Index:
LILACS
Main subject:
Urinary Incontinence
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Urinary Bladder, Neurogenic
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Botulinum Toxins, Type A
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Urinary Bladder, Overactive
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Neuromuscular Agents
Type of study:
Evaluation_studies
/
Observational_studies
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
/
Male
Language:
En
Journal:
Int. braz. j. urol
Journal subject:
UROLOGIA
Year:
2010
Type:
Article