blaCTX-M-2 and blaCTX-M-28 extended-spectrum â-lactamase genes and class 1 integrons in clinical isolates of Klebsiella pneumoniae from Brazil
Mem. Inst. Oswaldo Cruz
; 105(2): 163-167, Mar. 2010. tab
Article
in En
| LILACS
| ID: lil-544621
Responsible library:
BR1.1
ABSTRACT
Twenty-eight Klebsiella pneumoniae clinical isolates that exhibited an extended-spectrum cephalosporin-resistance profile from a city in the Northeast of Brazil were analysed by PCR and DNA sequencing in order to determine the occurrence of blaCTX-M genes and class 1 integrons. We determined the occurrence of the blaCTX-M-2 gene in six K. pneumoniae isolates and describe the first detection of the blaCTX-M-28 gene in South America. Seven isolates carried class 1 integrons. Partial sequencing analysis of the 5'-3'CS variable region in the class 1 integrons of three isolates revealed the presence of aadA1, blaOXA-2 and dfr22 gene cassettes.
Key words
Full text:
1
Index:
LILACS
Main subject:
Beta-Lactamases
/
DNA, Bacterial
/
Integrons
/
Klebsiella pneumoniae
Limits:
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2010
Type:
Article
/
Project document