blaCTX-M-2 and blaCTX-M-28 extended-spectrum â-lactamase genes and class 1 integrons in clinical isolates of Klebsiella pneumoniae from Brazil
Mem. Inst. Oswaldo Cruz
;
105(2): 163-167, Mar. 2010. tab
Article
in English
| LILACS
| ID: lil-544621
ABSTRACT
Twenty-eight Klebsiella pneumoniae clinical isolates that exhibited an extended-spectrum cephalosporin-resistance profile from a city in the Northeast of Brazil were analysed by PCR and DNA sequencing in order to determine the occurrence of blaCTX-M genes and class 1 integrons. We determined the occurrence of the blaCTX-M-2 gene in six K. pneumoniae isolates and describe the first detection of the blaCTX-M-28 gene in South America. Seven isolates carried class 1 integrons. Partial sequencing analysis of the 5'-3'CS variable region in the class 1 integrons of three isolates revealed the presence of aadA1, blaOXA-2 and dfr22 gene cassettes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Beta-Lactamases
/
DNA, Bacterial
/
Integrons
/
Klebsiella pneumoniae
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2010
Type:
Article
/
Project document
Affiliation country:
Brazil
/
Spain
Institution/Affiliation country:
Consejo Superior de Investigaciones Científicas/ES
/
Universidade Federal de Pernambuco/BR
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