Anti-hypertensive drugs have different effects on ventricular hypertrophy regression: [review]
Clinics
; 65(7): 723-728, 2010. tab
Article
in En
| LILACS
| ID: lil-555505
Responsible library:
BR1.1
ABSTRACT
OBJECTIVES:
There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature.METHODS:
The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy.RESULTS:
The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective â1 receptor antagonist) with respect to LVH regression.CONCLUSION:
The anti-hypertensive drugs induced various degrees of hypertrophic regression.Key words
Full text:
1
Index:
LILACS
Main subject:
Hypertrophy, Left Ventricular
/
Antihypertensive Agents
Type of study:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Animals
/
Humans
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2010
Type:
Article