Acute HIV infection with rapid progression to AIDS
Braz. j. infect. dis
; 14(3): 291-293, May-June 2010. ilus
Article
in En
| LILACS
| ID: lil-556844
Responsible library:
BR1.1
ABSTRACT
Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.
Key words
Full text:
1
Index:
LILACS
Main subject:
Pneumonia, Pneumocystis
/
AIDS-Related Opportunistic Infections
/
Disease Progression
/
Anti-HIV Agents
/
Pneumocystis carinii
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Braz. j. infect. dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2010
Type:
Article