Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
Mem. Inst. Oswaldo Cruz
; 105(6): 834-837, Sept. 2010. graf
Article
in En
| LILACS
| ID: lil-560672
Responsible library:
BR1.1
ABSTRACT
We have previously demonstrated selection favoring the JG strain of Trypanosoma cruziin hearts of BALB/c mice that were chronically infected with an equal mixture of the monoclonal JG strain and a clone of the Colombian strain, Col1.7G2. To evaluate whether cell invasion efficiency drives this selection, we infected primary cultures of BALB/c cardiomyocytes using these same T. cruzi populations. Contrary to expectation, Col1.7G2 parasites invaded heart cell cultures in higher numbers than JG parasites; however, intracellular multiplication of JG parasites was more efficient than that of Col1.7G2 parasites. This phenomenon was only observed for cardiomyocytes and not for cultured Vero cells. Double infections (Col1.7G2 + JG) showed similar results. Even though invasion might influence tissue selection, our data strongly suggest that intracellular development is important to determine parasite tissue tropism.
Key words
Full text:
1
Index:
LILACS
Main subject:
Trypanosoma cruzi
/
Tropism
/
Myocytes, Cardiac
/
Host-Parasite Interactions
Limits:
Animals
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2010
Type:
Article