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The cap gene of porcine circovirus type 2 (PCV2) evolves by positive selection in vitro / O gene cap de circovírus suíno tipo 2 (PCV2) evolui por seleção positiva in vitro
Brandão, Paulo Eduardo; Souza, Sibele Pinheiro de; Castro, Alessandra Marnie Martins Gomes de; Richtzenhain, Leonardo José.
Affiliation
  • Brandão, Paulo Eduardo; University of São Paulo. School of Veterinary Medicine. Department of Preventive Veterinary Medicine and Animal Health. BR
  • Souza, Sibele Pinheiro de; University of São Paulo. School of Veterinary Medicine. Department of Preventive Veterinary Medicine and Animal Health. BR
  • Castro, Alessandra Marnie Martins Gomes de; University of São Paulo. School of Veterinary Medicine. Department of Preventive Veterinary Medicine and Animal Health. BR
  • Richtzenhain, Leonardo José; University of São Paulo. School of Veterinary Medicine. Department of Preventive Veterinary Medicine and Animal Health. BR
Braz. j. vet. res. anim. sci ; 47(3): 209-212, mai.-jun. 2010. tab
Article in En | LILACS | ID: lil-561193
Responsible library: BR68.1
ABSTRACT
This article reports the genetic divergence of PCV2 after passages in VERO and SK-RST cell lines. Fisher’s exact test indicated a trend for positive selection on the cap gene. These results allow insights on the development of PCV2 vaccines and the evolution of the genus Circovirus.
RESUMO
Este artigo relata a divergência genética de PCV2 após passagens em células das linhagens VERO e SK-RST. O teste exato de Fisher indicou tendência para seleção positiva no gene cap. Estes resultados permitem inferências relativas ao desenvolvimento de vacinas contra PCV2 e sobre a evolução do gênero Circovirus.
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Index: LILACS Main subject: Selection, Genetic / Circovirus Limits: Animals Language: En Journal: Braz. j. vet. res. anim. sci Journal subject: MEDICINA VETERINARIA Year: 2010 Type: Article / Project document
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Index: LILACS Main subject: Selection, Genetic / Circovirus Limits: Animals Language: En Journal: Braz. j. vet. res. anim. sci Journal subject: MEDICINA VETERINARIA Year: 2010 Type: Article / Project document