Terapia génica en la insuficiencia cardiaca / Gene therapy for heart failure
Arch. cardiol. Méx
;
79(2): 147-156, abr.-jun. 2009. tab
Article
in Spanish
| LILACS
| ID: lil-565717
ABSTRACT
Gene therapy as a therapeutic strategy for Heart Failure, is an area that within the last 10 years has experienced an important increase in research, becoming one of the most promising areas to obtain a successful therapy for heart failure due to the possibility of correcting the basic defects observed at the cellular level in this pathology. One of the first things to consider on the use of this therapy is the way to deliver the genetic material, Adenovirus, and Adeno-associated virus, have shown the best capabilities in the myocardium; the delivery by local means has shown best results when compared with peripheral administration. Multiple physiopathological mechanisms susceptible of modifying by gene therapy have been identified, including the regulation of Ca2+ fluxes during excitation-contraction coupling, altered intracellular signalling, and adrenergic system, blockade of apoptosis and angiogenesis. The objective of this review, is to made a recount about the status of the literature and analyze future perspectives for gene therapy.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Genetic Therapy
/
Heart Failure
Type of study:
Systematic reviews
Limits:
Humans
Language:
Spanish
Journal:
Arch. cardiol. Méx
Journal subject:
Cardiology
Year:
2009
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Universidad Nacional Autónoma de México/MX
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