Predicción de sobrevida del injerto a corto y largo plazo mediante el uso de índices gamagráficos en receptores de trasplante renal / Prediction of short and long term graft survival by 99mTc-MAG3 scintigraphy after renal transplantation
Rev. med. nucl. Alasbimn j
; 12(49)July 2010. ilus, tab, graf
Article
in Es
| LILACS
| ID: lil-580221
Responsible library:
CL1.1
ABSTRACT
Background:
99Tcm-MAG3 is a non-invasive method for the evaluation of renal transplants, giving information about allograft function and short- and long-term allograft survival. However, few studies have validated this observation. Objetive To determine the predictive power of different scintigraphic parameters on graft survival at 6 -12 months after renal transplantation.Methods:
Between 1996-2007, receptors with varying degrees of kidney dysfunction were studied with 99mTc-MAG3 scintigraphy within 14 days after transplantation. Tubular injury score (TISS) ranging I-VI according to severity and renal extraction index (R20/3) were calculated. Survival analysis and Cox regression were used for analysis.Results:
Three-hundred and four renograms were performed in 146 allografts (143 receptors, mean age 38.9 +/- 17 years, 81.5 percent from cadaveric donor). Mean follow-up time was 44 months. There was graft loss (GL) in 32 percent renal trasplants. According to severity range, graft survival at 6 and 12 months was TISS I-II 85.23 percent and 81.17 percent; TISS III-IV 82.43 percent and 80.56 percent, and TISS V-VI 32 percent and 2.,43 percent respectively. TISS score of V-VI score was an independent predictor for GL (HR = 6.3 CI 95 percent 2.913; p<0.0001). R20/3 index was not a good predictor of GL.Conclusions:
TISS score was an independent predictor of short- and long-term allograft survival using 99mTc-MAG3 scintigraphy performed early after kidney transplantation in patients with suspected patients renal dysfunction. TISS V-VI had a greater discriminatory power. R20/3 index individually did not present a good prognostic performance.Key words
Full text:
1
Index:
LILACS
Main subject:
Kidney Transplantation
/
Graft Survival
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Es
Journal:
Rev. med. nucl. Alasbimn j
Journal subject:
MEDICINA NUCLEAR
Year:
2010
Type:
Article