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Modulation of drug resistance in Staphylococcus aureus by extract of mango (Mangifera indica L., Anacardiaceae) peel
Oliveira, Susy Mary Souto de; Falcão-Silva, Vivyanne S; Siqueira-Junior, José P; Costa, Maria José de Carvalho; Diniz, Margareth de Fátima F. de Melo.
Affiliation
  • Oliveira, Susy Mary Souto de; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Produtos Naturais e Sintéticos Bioativos. João Pessoa. BR
  • Falcão-Silva, Vivyanne S; Universidade Federal da Paraíba. Centro de Ciências Exatas e da Natureza. Departamento de Biologia Molecular. Laboratório de Genética de Microrganismos. João Pessoa. BR
  • Siqueira-Junior, José P; Universidade Federal da Paraíba. Centro de Ciências Exatas e da Natureza. Departamento de Biologia Molecular. Laboratório de Genética de Microrganismos. João Pessoa. BR
  • Costa, Maria José de Carvalho; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Ciências da Nutrição. João Pessoa. BR
  • Diniz, Margareth de Fátima F. de Melo; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Produtos Naturais e Sintéticos Bioativos. João Pessoa. BR
Rev. bras. farmacogn ; 21(1): 190-193, jan.-fev. 2011. tab
Article in En | LILACS | ID: lil-580337
Responsible library: BR1.1
ABSTRACT
In an ongoing project to evaluate natural compounds isolated from by-products or wastes from vegetables and fruits (edible plants) as modulators of antibiotic resistance, ethanol extract from mango peel was investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance to norfloxacin, erythromycin and tetracycline. The minimum inhibitory concentrations (MIC) of the antibiotics were determined by the micro dilution assay in the absence and in the presence of sub-inhibitory mango peel extract concentration. Although the extract did not display relevant antibacterial activity (MIC>2048 µg/mL), it modulated the activity of antibiotics, i.e. in combination with antibiotics (at 512 µg/mL), a four-fold reduction in the MIC values for tetracycline and erythromycin was observed. The results presented here indicates that mango peel could serve as a source of potential adjuvant of antibiotics which add value to this mango by-product.
Key words

Full text: 1 Index: LILACS Language: En Journal: Rev. bras. farmacogn Journal subject: FARMACIA Year: 2011 Type: Article

Full text: 1 Index: LILACS Language: En Journal: Rev. bras. farmacogn Journal subject: FARMACIA Year: 2011 Type: Article