HOXB5 expression in oral squamous cell carcinoma
J. appl. oral sci
; 19(2): 125-129, May-Apr. 2011. ilus
Article
in En
| LILACS
| ID: lil-586032
Responsible library:
BR1.1
ABSTRACT
Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE:
The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics. MATERIAL ANDMETHODS:
RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verifed by the chi-square and post-hoc t-test.RESULTS:
HOXB5 was amplifed in 60 percent non-tumoral epithelium and in 93.3 percent carcinomas. No statistically signifcant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade.CONCLUSION:
HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.Key words
Full text:
1
Index:
LILACS
Main subject:
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Gene Expression Regulation, Neoplastic
/
Homeodomain Proteins
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
J. appl. oral sci
Journal subject:
ODONTOLOGIA
Year:
2011
Type:
Article
/
Project document