Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
Mem. Inst. Oswaldo Cruz
; 106(4): 505-506, June 2011.
Article
in En
| LILACS
| ID: lil-592196
Responsible library:
BR1.1
ABSTRACT
The aim of the current study was to describe the occurrence of the blaOXA-23 gene and the ISAba1 element in imipenem-susceptible Acinetobacter baumannii strains. By performing the polymerase chain reaction mapping using combinations of ISAba1 forward primers and the blaOXA-23-like gene reverse primers, we demonstrated that the ISAba1 element did not occur upstream of the blaOXA-23 gene in five of 31 isolates, which explained the lack of resistance to imipenem despite the presence of the blaOXA-23 gene. All of the blaOXA-23-positive isolates were susceptible to imipenem and meropenem with minimal inhibitory concentration < 4 µg/mL. Pulsed-field gel electrophoresis analysis revealed four genotypes among the five blaOXA-23-positive isolates. The current report of the blaOXA-23 gene in imipenem-susceptible isolates provided evidence that this gene may be silently spread in a hospital environment and highlighted the threat of undetected reservoirs of carbapenemase genes.
Key words
Full text:
1
Index:
LILACS
Main subject:
Beta-Lactamases
/
Imipenem
/
Drug Resistance, Bacterial
/
Acinetobacter baumannii
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2011
Type:
Article