Sangre segura en ausencia de infecciones virales por VHB, VHC y VIH en período de ventana serológica de donadores
Salud pública Méx
; 53(supl.1): S13-S18, 2011. tab
Article
in Es
| LILACS
| ID: lil-597118
Responsible library:
BR1.1
RESUMEN
OBJETIVO:
Determinar la prevalencia de infecciones virales (VHB, VHC y VIH) en período de ventana serológica en donadores de sangre evaluados con la prueba de ácidos nucleicos (NAT). MATERIALES YMÉTODOS:
Se incluyeron donadores de sangre evaluados de 2008 a 2009 con pruebas serológicas y moleculares del VHB, VHC y VIH. El período de ventana serológica se definió con la prueba de NAT positiva y la prueba serológica negativa.RESULTADOS:
Durante un año se evaluaron 47 847 donadores de sangre; no se identificó ningún caso con infección viral (VHB, VHC y VIH) en período de ventana serológica; únicamente se demostró NAT positivo en donadores con pruebas serológicas positivas 26 de 78 con VHB, 56 de 318 con VHC y 16 de 155 con VIH.CONCLUSIÓN:
Este es el primer estudio en México que demostró en donadores de sangre la ausencia de infecciones virales (VHB, VHC y VIH) en período de ventana serológica con la prueba de NAT.ABSTRACT
OBJECTIVE:
To determine the prevalence of viral infections (HBV, HCV and HIV) in serological window period in blood donors screened with nucleic acid testing (NAT). MATERIALS ANDMETHODS:
We assessed all blood donors from July 2008 to June 2009 at the Central Blood Bank of the Mexican Institute of Social Security. Medical history was made and provided an information brochure and self-exclusion questionnaire. All blood donors were tested with serological tests (Ag-HBVs, Anti-HCV and Anti-HIV) and molecular testing with NAT for HBV, HCV and HIV. The window period was defined with the positive NAT and negative serological test.RESULTS:
During one year, we evaluated 47 847 blood donors. None subject was identified with viral infection (HBV, HCV and HIV) in serological window period. Positive serological testing were found for HBV in 78 (0.2 percent), 318 (0.7 percent) for HCV and 155 (0.3 percent) for HIV. Positive NAT was demonstrated only in donors with positive serology 26 of 78 with HBV, 56 of 318 with HCV and 16 of 155 with HIV.CONCLUSION:
This is the first study in México showed no viral infections (HBV, HCV and HIV) during serological window period in blood donors; The medical history and the self-exclusion questionnaire help to improve blood transfusion safety.Key words
Full text:
1
Index:
LILACS
Main subject:
Blood Donors
/
Blood Transfusion
/
Serologic Tests
/
HIV Infections
/
Hepatitis C
/
Infectious Disease Incubation Period
/
Blood Safety
/
Hepatitis B
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Humans
Country/Region as subject:
Mexico
Language:
Es
Journal:
Salud pública Méx
Journal subject:
SAUDE PUBLICA
Year:
2011
Type:
Article