Characterization of adrenergic control of the Leydig cell steroidogenesis: identification of both stimulatory and inhibitory components
Braz. j. med. biol. res
; 21(3): 539-43, Mar. 1988. ilus
Article
in En
| LILACS
| ID: lil-60249
Responsible library:
BR1.1
ABSTRACT
Percoll-purified Leydig cells were studied in vitro in order to evaluate the effect of adrenaline on testosterone (T) secretion. Adrenaline enhanced the basal and potentiated the hCG-induced T release. A similar effect was also obtained with the ß2-agonist, salbutamol. Although phenyleprine, an alfa1-agonist, did not alter the basal T secretion, it enhanced hCG-mediated T secretion. Para-aminoclonidine, an alfa2-agonist, decreased the basal T release without altering the HCG-stimulated T release. These data demonstrate that either inhibitory or stimulatory effects on T release can be obtained and that they depend on the adrenoreceptor subtype involved
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Index:
LILACS
Main subject:
Testosterone
/
In Vitro Techniques
/
Epinephrine
/
Receptors, Adrenergic
/
Chorionic Gonadotropin
/
Leydig Cells
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1988
Type:
Article
/
Congress and conference