Enfermedad de Cushing recidivada después de tratamiento quirúrgico exitoso: a propósito de un caso clínico / Relapse of cushing disease after excision of a pituitary adenoma: report of one case / Relapse of cushing disease after excision of a pituitary adenoma: report of one case

ABSTRACT

Cushing´s disease results from overproduction of glucocorticoids due to excessive corticotropin secretion by a tumor of the pituitary gland´s corticotroph cells and is the cause of 80 percent of all forms of ACTH dependent hypercortisolism. Both its diagnosis and treatment represent a challenge and transsphenoidal surgical resection is currently the treatment of choice.The success of the surgery depends on the tumor size and on the experience of the center which performs the intervention, achieving remission of the disease in around 70 percent of microadenomas and 15 percent of tumors larger than 1 cm. Among patients who achieved control of hypercortisolism, there is a relapse rate that fluctuates between 5 and 25 percent. The clash of these cases represents an even greater challenge than the previous one, especially with regard to the treatment. We report the case of a 30 years old woman with Cushing's disease, operated on and cured through a transsphenoidal resection, who relapsed 10 years after surgery.