Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients
Clinics
; 67(4): 313-318, 2012. ilus, tab
Article
in En
| LILACS
| ID: lil-623109
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To describe the chest computed tomography findings for severe influenza H1N1 infection in a series of hospitalized neutropenic cancer patients.METHODS:
We performed a retrospective systematic analysis of chest computed tomography scans for eight hospitalized patients with fever, neutropenia, and confirmed diagnoses of influenza H1N1. The clinical data had been prospectively collected.RESULTS:
Six of eight patients (75%) developed respiratory failure and required intensive care. Prolonged H1N1 shedding was observed in the three mechanically ventilated patients, and overall hospital mortality in our series was 25%. The most frequent computed tomography findings were ground-glass opacity (all patients), consolidation (7/8 cases), and airspace nodules (6/8 cases) that were frequently moderate or severe. Other parenchymal findings were not common. Five patients had features of pneumonia, two had computed tomography findings compatible with bronchitis and/or bronchiolitis, and one had tomographic signs of chronicity.CONCLUSION:
In this series of neutropenic patients with severe influenza H1N1 infection, chest computed tomography demonstrated mainly moderate or severe parenchymatous disease, but bronchiolitis was not a common feature. These findings associated with febrile neutropenia should elicit a diagnosis of severe viral infection.Key words
Full text:
1
Index:
LILACS
Main subject:
Pneumonia, Viral
/
Tomography, X-Ray Computed
/
Influenza, Human
/
Influenza A Virus, H1N1 Subtype
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Neoplasms
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Neutropenia
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Child, preschool
/
Female
/
Humans
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2012
Type:
Article