Variantes genéticas de CYP2A6 y su relación con la dependencia tabáquica y el hábito de fumar en una muestra individuos chilenos: Un estudio piloto / Relation of genetic variants of CYP2A6 with tobacco dependence and smoking habit in Chilean subjects: A pilot study
Rev. méd. Chile
; 140(4): 436-441, abr. 2012. ilus
Article
in Es
| LILACS
| ID: lil-643212
Responsible library:
CL1.1
ABSTRACT
Background:
Genetic and metabolic factors associated with nicotine metabolism may be related to smoking behavior.Aim:
To assess the prevalence of allelic and genotype variants of CYP2A6 in a sample of Chilean subjects and to evaluate their relationship with smoking and tobacco dependence. Material andMethods:
The genotype frequencies for *2, *3 and *4 of CYP2A6*1 (wild type) gene were determined by polymerase chain reaction (PCR) in 54 volunteers. Addiction to tobacco was evaluated using the Fagerstrom Test. The association between the presence of allelic variants of CYP2A6 and smoking and tobacco dependence was evaluated with chi square test.Results:
The prevalence of *1, *2 (wt/*2), *3 (wt/*3 or *31*3) and *4 (del/del) were 92.6%, 3.7%, 0% y 3.7%, respectively. No significant association was observed between being a carrier of a variant genotype of CYP2A6 and smoking or tobacco dependence.Conclusions:
In this sample of Chilean individuals we did not find a relation between any CYP2A6 genotype with smoking or tobacco dependence.Key words
Full text:
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Index:
LILACS
Main subject:
Polymorphism, Genetic
/
Tobacco Use Disorder
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Aryl Hydrocarbon Hydroxylases
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Smoking
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
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Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Chile
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2012
Type:
Article
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Project document