Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents
Clinics
; 67(10): 1209-1214, Oct. 2012. ilus, tab
Article
in En
| LILACS
| ID: lil-653486
Responsible library:
BR1.1
ABSTRACT
OBJECTIVES:
The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life.METHOD:
The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol.RESULTS:
Body weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (>7 times), bradycardic responses (>4 times), and vagal (~38%) and sympathetic effects (~36%) were reduced as compared to the control group.CONCLUSION:
Our results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance.Key words
Full text:
1
Index:
LILACS
Main subject:
Sodium Glutamate
/
Autonomic Nervous System
/
Cardiovascular Physiological Phenomena
/
Food Additives
/
Heart
/
Obesity
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2012
Type:
Article