Medical management of non-obstructive azoospermia
Clinics
; 68(supl.1): 75-79, 2013. tab
Article
in En
| LILACS
| ID: lil-668039
Responsible library:
BR1.1
ABSTRACT
Non-obstructive azoospermia is diagnosed in approximately 10% of infertile men. It represents a failure of spermatogenesis within the testis and, from a management standpoint, is due to either a lack of appropriate stimulation by gonadotropins or an intrinsic testicular impairment. The former category of patients has hypogonadotropic hypogonadism and benefits from specific hormonal therapy. These men show a remarkable recovery of spermatogenic function with exogenously administered gonadotropins or gonadotropin-releasing hormone. This category of patients also includes some individuals whose spermatogenic potential has been suppressed by excess androgens or steroids, and they also benefit from medical management. The other, larger category of non-obstructive azoospermia consists of men with an intrinsic testicular impairment where empirical medical therapy yields little benefit. The primary role of medical management in these men is to improve the quantity and quality of sperm retrieved from their testis for in vitro fertilization. Gonadotropins and aromatase inhibitors show promise in achieving this end point.
Key words
Full text:
1
Index:
LILACS
Main subject:
Aromatase Inhibitors
/
Azoospermia
/
Chorionic Gonadotropin
Type of study:
Etiology_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2013
Type:
Article