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Imatinib activity on Schistosoma mansoni
Katz, Naftale; Couto, Flavia Fernanda Bubulo; Araujo, Neusa.
Affiliation
  • Katz, Naftale; Fiocruz. Centro de Pesquisas Rene Rachou. Laboratorio de Esquistossomose. Belo Horizonte. BR
  • Couto, Flavia Fernanda Bubulo; Fiocruz. Centro de Pesquisas Rene Rachou. Laboratorio de Esquistossomose. Belo Horizonte. BR
  • Araujo, Neusa; Fiocruz. Centro de Pesquisas Rene Rachou. Laboratorio de Esquistossomose. Belo Horizonte. BR
Mem. Inst. Oswaldo Cruz ; 108(7): 850-853, 1jan. 2013. tab, graf
Article in En | LILACS | ID: lil-696014
Responsible library: BR1.1
ABSTRACT
Imatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses of 25 µM, 50 µM and 100 µM. The first drug activity observed with the lower dose was interruption of egg-laying and with the higher dosages was the death of the worms. In mice infected with S. mansoni no activity was found even with 1,000 mg/kg/day, 500 mg/kg/day, single oral dose or when administered for three consecutive days. This is another example of the difference of results related to in vitro and in vivo trials using S. mansoni worms.
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Full text: 1 Index: LILACS Main subject: Piperazines / Pyrimidines / Schistosoma mansoni / Schistosomicides / Benzamides / Schistosomiasis mansoni Limits: Animals Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2013 Type: Article

Full text: 1 Index: LILACS Main subject: Piperazines / Pyrimidines / Schistosoma mansoni / Schistosomicides / Benzamides / Schistosomiasis mansoni Limits: Animals Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2013 Type: Article