Hight chlorpromazine doses and liver function
Braz. j. med. biol. res
; 22(3): 351-3, 1989. tab
Article
in En
| LILACS
| ID: lil-70690
Responsible library:
BR26.1
ABSTRACT
The aim of the present study was to evaluate the in vivo effect of high chlorpromazine (CPZ) doses on hepatocellular function. Thirty male Wistar rats weighing 200 to 250 g were divided into two groups control (C, N = 17), injected ip with saline, and CPZ (N = 13), injected ip with high chlorpromazine doses (initial dose of 30 mg/Kg body weight followed by daily doses of 10 mg/Kg for 7 days). No significant differences in serum levels of alanine-aminotransferase, alkaline phosphatase and bilirubin or in mitochondrial function (activated and basal respiration and mitochondrial respiration control(activated/basal ratio) were detected between the two groups
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Index:
LILACS
Main subject:
Mitochondria, Liver
/
Chlorpromazine
/
Liver
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1989
Type:
Article