The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
Mem. Inst. Oswaldo Cruz
;
109(3): 362-364, 06/2014. graf
Article
in English
| LILACS
| ID: lil-711731
ABSTRACT
Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).
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LILACS (Americas)
Main subject:
Trypanocidal Agents
/
Trypanosoma cruzi
/
Diamines
/
Amino Alcohols
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Pesquisas René Rachou-Fiocruz/BR
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