Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: casual or related events?
An. bras. dermatol
; 89(5): 806-807, Sep-Oct/2014. graf
Article
in En
| LILACS
| ID: lil-720779
Responsible library:
BR1.1
ABSTRACT
A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of hypomelanosis around multiple preexisting nevi of the trunk. At 18 months follow-up genital depigmentation persisted and halo nevi of the trunk were still present. Different mechanisms of imiquimod-induced depigmentation have been reported. Halo nevi are considered expression of an autoimmune response. In the case presented here, it might be conceivable that both vitiligo-like depigmentation at the site of application and halo of hypomelanosis around melanocytic nevi have been induced by the same immunologic mechanism elicited by topical application of imiquimod.
Key words
Full text:
1
Index:
LILACS
Main subject:
Vitiligo
/
Vulvar Diseases
/
Condylomata Acuminata
/
Adjuvants, Immunologic
/
Nevus, Halo
/
Aminoquinolines
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
An. bras. dermatol
Journal subject:
DERMATOLOGIA
Year:
2014
Type:
Article