Chronic granulomatous disease: why an inflammatory disease?
Braz. j. med. biol. res
;
47(11): 924-928, 11/2014.
Article
in English
| LILACS
| ID: lil-723900
ABSTRACT
Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
NADPH Oxidases
/
Granulomatous Disease, Chronic
/
Neutrophils
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
Similar
MEDLINE
...
LILACS
LIS