Interferon-γ inhibits group B Streptococcus survival within human endothelial cells
Mem. Inst. Oswaldo Cruz
;
109(7): 940-943, 11/2014. graf
Article
in English
| LILACS
| ID: lil-728811
ABSTRACT
Endothelial dysfunction is a major component of the pathophysiology of septicaemic group B Streptococcus (GBS) infections. Although cytokines have been shown to activate human umbilical vein endothelial cells (HUVECs), the capacity of interferon (IFN)-γ to enhance the microbicidal activity of HUVECs against GBS has not been studied. We report that the viability of intracellular bacteria was reduced in HUVECs activated by IFN-γ. Enhanced fusion of lysosomes with bacteria-containing vacuoles was observed by acid phosphatase and the colocalisation of Rab-5, Rab-7 and lysosomal-associated membrane protein-1 with GBS in IFN-γ-activated HUVECs. IFN-γ resulted in an enhancement of the phagosome maturation process in HUVECs, improving the capacity to control the intracellular survival of GBS.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Streptococcal Infections
/
Streptococcus agalactiae
/
Interferon-gamma
/
Microbial Viability
/
Human Umbilical Vein Endothelial Cells
/
Anti-Infective Agents
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio de Janeiro/BR
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