High similarity of Trypanosoma cruzi kDNA genetic profiles detected by LSSP-PCR within family groups in an endemic area of Chagas disease in Brazil
Rev. Soc. Bras. Med. Trop
; 47(5): 653-656, Sep-Oct/2014. graf
Article
in En
| LILACS
| ID: lil-728908
Responsible library:
BR1.1
ABSTRACT
Introduction Determining the genetic similarities among Trypanosoma cruzi populations isolated from different hosts and vectors is very important to clarify the epidemiology of Chagas disease. Methods An epidemiological study was conducted in a Brazilian endemic area for Chagas disease, including 76 chronic chagasic individuals (96.1% with an indeterminate form; 46.1% with positive hemoculture). Results T. cruzi I (TcI) was isolated from one child and TcII was found in the remaining (97.1%) subjects. Low-stringency single-specific-primer-polymerase chain reaction (LSSP-PCR) showed high heterogeneity among TcII populations (46% of shared bands); however, high similarities (80-100%) among pairs of mothers/children, siblings, or cousins were detected. Conclusions LSSP-PCR showed potential for identifying similar parasite populations among individuals with close kinship in epidemiological studies of Chagas disease. .
Key words
Full text:
1
Index:
LILACS
Main subject:
Trypanosoma cruzi
/
DNA, Protozoan
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Chagas Disease
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DNA, Kinetoplast
Limits:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
MEDICINA TROPICAL
Year:
2014
Type:
Article
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Project document