Correlación de valores de TTPa con anti factor Xa para establecer rango terapéutico en tratamiento anticoagulante con heparina sódica / Correlation between aPTT and antifactor Xa to determine therapeutic ranges for unfractionated heparin
Rev. méd. Chile
; 142(11): 1392-1397, nov. 2014. graf, tab
Article
in Es
| LILACS
| ID: lil-734874
Responsible library:
CL1.1
ABSTRACT
Background:
The therapeutic range (TR) of activated partial thromboplastin time (aPTT) for unfractionated heparin (UFH) dosing was established in the 1970 decade. Since then aPTT determination has changed. Current TR may be sub or supra-therapeutic depending on the reagents of the test, and therefore, responsible for complications of therapy.Aim:
To establish the TR for UFH dosing in our institution using antifactor Xa analysis as reference standard. Material andMethods:
After obtaining an informed consent, 43 blood samples were obtained for aPTT determination and antifactor Xa assay in 23 patients treated with intravenous UFH. Samples were processed at Emergency and Hemostasis Labs. We excluded patients receiving other anticoagulants, with thrombophilia, pregnancy or liver disease.Results:
Mean aPTT values in the Hemostasis and Emergency labs were 57.1 ± 18.9 and 56.6 ± 18.3 seconds, respectively (p = 0.77). The squared correlation coefficients between aPTT and antifactor Xa at hemostasis and emergency labs were R2 0.5 and 0.45 respectively, p < 0.001. Using a linear regression analysis, therapeutic aPTT range values in our laboratory were established between 50 and 80 seconds, corresponding to antifactor Xa values of 0.3 to 0.7 IU/mL.Conclusions:
According to current recommendations, validation of aPTT determination with reference techniques should be done in every institution.Key words
Full text:
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Index:
LILACS
Main subject:
Partial Thromboplastin Time
/
Heparin
/
Factor Xa Inhibitors
/
Anticoagulants
Type of study:
Diagnostic_studies
/
Guideline
Limits:
Humans
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2014
Type:
Article