Effect of propranolol on capsular reaction around silicone implants in guinea pigs
Acta cir. bras
; 30(1): 24-33, 01/2015. tab, graf
Article
in En
| LILACS
| ID: lil-735711
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model.METHODS:
Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).RESULTS:
Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant.CONCLUSION:
Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface. .Key words
Full text:
1
Index:
LILACS
Main subject:
Propranolol
/
Adrenergic beta-Antagonists
/
Silicone Gels
/
Implant Capsular Contracture
Type of study:
Clinical_trials
/
Evaluation_studies
/
Prognostic_studies
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article