Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice
Acta cir. bras
; 30(4): 242-246, 04/2015. graf
Article
in En
| LILACS
| ID: lil-744278
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.METHODS:
The anti-inflammatory effect of alcoholic extracts of green tea (AE) was evaluated in a cell migration assay with four groups of six Swiss mice receiving 0.07g/Kg or 0.14g/Kg EA (treatment groups), saline (negative control) or 10mg/Kg indomethacin (positive control) by gavage. One hour later 300 µg carrageen an was administered intraperitoneally or subcutaneously. The analgesic effect was evaluated using four groups of six animals receiving 0.07g/Kg or 0.14g/Kg EA, saline or 10mg/Kg indomethacin subcutaneously, followed 30 minutes later by 1% acetic acid.RESULTS:
When administered subcutaneously at either dose (0.07g/Kg and 0.14g/Kg), AE inhibited carrageenan-induced cell migration (p<0.05). However, when administered by gavage, only the latter (0.14 g/Kg) was efficient (p<0.05). AE at both doses (0.07g/Kg and 0.14g/Kg) inhibited abdominal contortions (p<0.05), but the effect was not dose-dependent.CONCLUSION:
Green tea was shown to have analgesic and anti-inflammatory properties and may constitute a natural treatment option in chronic inflammatory disorders. .Key words
Full text:
1
Index:
LILACS
Main subject:
Tea
/
Plant Extracts
/
Camellia sinensis
/
Analgesics
/
Phytotherapy
/
Anti-Inflammatory Agents
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article