Mannitol versus hypertonic saline for brain relaxation in patients undergoing craniotomy
São Paulo med. j
; 133(2): 166-167, Mar-Apr/2015.
Article
in En
| LILACS
| ID: lil-746655
Responsible library:
BR1.1
ABSTRACT
BACKGROUND:
Patients with brain tumour usually suffer from increased pressure in the skull due to swelling of brain tissue. A swollen brain renders surgical removal of the brain tumour difficult. To ease surgical tumour removal, measures are taken to reduce brain swelling, often referred to as brain relaxation. Brain relaxation can be achieved with intravenous fluids such as mannitol or hypertonic saline. This review was conducted to find out which of the two fluids may have a greater impact on brain relaxation.OBJECTIVES:
To compare the effects of mannitol versus those of hypertonic saline on intraoperative brain relaxation in patients undergoing craniotomy.METHODS:
Searchmethods:
We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (2013, Issue 10), Medline via Ovid SP (1966 to October 2013) and Embase via Ovid SP (1980 to October 2013). We also searched specific websites, such as www.indmed.nic.in, www.cochrane-sadcct.org and www.Clinicaltrials.gov. Selection criteria We included randomized controlled trials (RCTs) that compared the use of hypertonic saline versus mannitol for brain relaxation. We also included studies in which any other method used for intraoperative brain relaxation was compared with mannitol or hypertonic saline. Primary outcomes were longest follow-up mortality, Glasgow Outcome Scale score at three months and any adverse events related to mannitol or hypertonic saline. Secondary outcomes were intraoperative brain relaxation, intensive care unit (ICU) stay, hospital stay and quality of life. Data collection andanalysis:
We used standardized methods for conducting a systematic review, as described by the Cochrane Handbook for Systematic Reviews of Interventions. Two review authors independently extracted details of trial methodology and outcome data from reports of all trials considered eligible for inclusion. All analyses were made on an intention-to-treat basis. We used a fixed-effect ...
Full text:
1
Index:
LILACS
Main subject:
Saline Solution, Hypertonic
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Brain Neoplasms
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Craniotomy
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Encephalitis
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Hypertonic Solutions
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Mannitol
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Female
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Humans
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Male
Language:
En
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
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Cincia
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Ginecologia
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MEDICINA
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Medicina Interna
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Obstetr¡cia
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Pediatria
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Sa£de Mental
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Sa£de P£blica
Year:
2015
Type:
Article