Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
Clinics
;
70(3): 169-172, 03/2015. tab
Article
in English
| LILACS
| ID: lil-747107
ABSTRACT
BACKGROUND:
To evaluate the macrophage migration inhibitory factor and E-selectin levels in patients with acute coronary syndrome. MATERIALS/METHODS:
We examined the plasma migration inhibitory factor and E-selectin levels in 87 patients who presented with chest pain at our hospital. The patients were classified into two groups according to their cardiac status. Sixty-five patients had acute myocardial infarction, and 22 patients had non-cardiac chest pain (non-coronary disease). We designated the latter group of patients as the control group. The patients who presented with acute myocardial infarction were further divided into two subgroups ST-elevated myocardial infarction (n = 30) and non-ST elevated myocardial infarction (n = 35).RESULTS:
We found higher plasma migration inhibitory factor levels in both acute myocardial infarction subgroups than in the control group. However, the E-selectin levels were similar between the acute myocardial infarction and control patients. In addition, we did not find a significant difference in the plasma migration inhibitory factor levels between the ST elevated myocardial infarction and NST-elevated myocardial infarction subgroups.DISCUSSION:
The circulating concentrations of migration inhibitory factor were significantly increased in acute myocardial infarction patients, whereas the soluble E-selectin levels were similar between acute myocardial infarction patients and control subjects. Our results suggest that migration inhibitory factor may play a role in the atherosclerotic process. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
T-Lymphocytes, Cytotoxic
/
Mammary Neoplasms, Animal
/
Interferon-gamma
/
T-Lymphocytes, Helper-Inducer
/
Spheroids, Cellular
Type of study:
Risk factors
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2015
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Izmir Bozyaka Training and Research Hospital/TR
Similar
MEDLINE
...
LILACS
LIS