Anxiolytic effect of carbamazepine measured in the elevated plu-maze

RESUMO

the anxiolytic effect of carba,zepine was measured in rats placed in an elevated plus-maze. Doses from 5 to 40 mg/Kg, ip, of carbamazepine increased the percentage of open arm entries as well as the percentage of time spent in the two opwn arms of the maze. Both of these measures ar interpreted as indexes of anxiety. The total number of entries in either the open or the two enclosed arms, considered as an index of general activity, was not changed by the drug. Therefore, carbamzepine, carba,azepine caused a selective anxiolytic effect as measured in the elevated plus-maze, which is predictive of clinical efficacy