Participation of the serotonergic system in the regulation of water and electrolyte balance
Braz. j. med. biol. res
; 22(6): 761-3, June 1989. ilus
Article
in En
| LILACS
| ID: lil-75231
Responsible library:
BR26.1
ABSTRACT
To determine the possible participation of the serotonergic (5-Ht system in the regulation of water and electrolyte balance, rats were submitted to two sessions of water overloading and the 5-HT agonist MK 212 was administered intracerebroventricularly (icv) in 1.0 micronl 20 min after the second session. Urine volume and sodium and potassium excretion were measured over a priod of 120 min. Microinjection of MK-212 (1 microng/animal) caused a significant reduction (24 to 57%; mean, 43%) in natriuresis throghout the experimental period, and the administration of 10 microng/animal caused a 26-41% reduction (mean, 33%) in kaliuresis. At 20 microng/ animal, MK-212 did not change any of the parameters investigated. No significant change in urine volume was detected after any of the reatments used
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Index:
LILACS
Main subject:
Pyrazines
/
Water-Electrolyte Balance
/
Serotonin
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1989
Type:
Article
/
Congress and conference