Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente? / Differences by age in clinical features of inflammatory bowel disease
Rev. méd. Chile
; 143(6): 689-696, jun. 2015. ilus, tab
Article
in Es
| LILACS
| ID: lil-753508
Responsible library:
CL1.1
ABSTRACT
Background:
Approximately, 15% of patients with Inflammatory Bowel Disease (IBD) are diagnosed at 60 years of age or more.Aim:
To characterize and compare clinical variables between patients with IBD aged 60 years or more and their younger counterparts. Material andMethods:
Retrospective study based on a registry of IBD patients diagnosed between the years 1976 and 2014.Results:
Four hundred and nine IBD patients were included. Among them, 294 had Ulcerative Colitis (UC), 104 had Crohn s Disease (CD) and eleven had an indeterminate IBD. Forty-six patients (11.2%) were older than 60 years and 16 (3.9%) had been diagnosed after this age. When comparing patients by age, those aged 60 years or more had a higher frequency of CD and indeterminate IBD (p < 0.01) and a lower ileocolic location in CD (p = 0.02). Both groups were similar in terms of hospitalization due to IBD flare, surgery, use of steroids, immunosuppressive or biological therapies and drug-related adverse events. When analyzing age at diagnosis of IBD, patients diagnosed at ages of 60 years or more had a lower frequency of UC (p < 0.01), a higher frequency of exclusive colonic involvement (p = 0.01), and lower use of mesalamine (p < 0.01). There were no differences in drug-related adverse events, hospitalizations due to IBD flares and surgery according to age at diagnosis.Conclusions:
In this population, clinical features of IBD in older patients were similar to those in younger patients.Key words
Full text:
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Index:
LILACS
Main subject:
Inflammatory Bowel Diseases
/
Age Factors
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
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Observational_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Female
/
Humans
/
Male
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2015
Type:
Article
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Project document