Does dexamethasone act in neuropeptides SP and CGRP in neurogenic inflammation of the skin? An experimental study
Acta cir. bras
; 30(8): 523-528, Aug. 2015. ilus
Article
in En
| LILACS
| ID: lil-757990
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats.METHODS:
Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) was injected with 10.0 mg/kg dexamethasone. In all groups, the three subcutaneous injections were performed 30 minutes prior to the surgical skin incision and tissue collection. SP and CGRP (15 kDa pro-CGRP and 5 kDa CGRP) were quantified by Western Blotting.RESULTS:
No statistically significant differences (p>0.05) were found in pro-CGRP, CGRP and SP values in all three groups.CONCLUSION:
The anti-inflammatory effect of dexamethasone did not occur when the substance P and calcitonin gene-related peptide levels were altered during the neurogenic inflammation process of skin wound healing in rats.Key words
Full text:
1
Index:
LILACS
Main subject:
Dexamethasone
/
Substance P
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Calcitonin Gene-Related Peptide
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Neurogenic Inflammation
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Dermatitis
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Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article
/
Project document