Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review / Critérios de neuroimagem e desempenho cognitivo no comprometimento cognitivo leve vascular: uma revisão sistemática
Dement. neuropsychol
; 9(4): 394-404, Oct.-Dec. 2015. tab, graf
Article
in En
| LILACS
| ID: lil-770582
Responsible library:
BR15.3
ABSTRACT
ABSTRACT The recognition of Cerebrovascular Disease (CVD) at earlier clinical stages may favor the control of vascular risk factors and prevention of dementia. However, operational criteria for symptomatic phases at non-dementia stages are often difficult, as the current criteria normally require the evidence of extensive subcortical disease. OBJECTIVE To identify the neuroimaging profile of Vascular Mild Cognitive Impairment (VaMCI), the impact of those aspects over cognition and the neuropsychological tests that distinguished VaMCI from other groups. METHODS Searches were performed in Scopus, ISI and PsycINFO, using the following key terms "vascular mild cognitive impairment" OR "vascular cognitive impairment no dementia" OR "vascular cognitive impairment not demented" OR "subcortical mild cognitive impairment". RESULTS Of 249 papers, 20 studies were selected. Ten of those included only patients with severe White Matter Hyperintensities (WMH), whereas 10 others admitted subjects with moderate-to-severe WMH. Both groups showed poor performances in Executive Function (EF) tasks in comparison to normal controls and other diagnostic groups. Among EF tests, those assessing "complex" EF abilities consistently distinguished VaMCI from other groups, regardless of the severity of WMH. VaMCI subjects with severe or moderate-to-severe WMH showed cognitive deficits in comparison with other groups. "Complex" EF tests were the most useful in differentiating those patients from the other groups. CONCLUSION The occurrence of VaMCI may be associated with the presence of CVD at moderate levels; the detection of vascular damage at earlier stages may allow the adoption of therapeutic actions with significant effect-sizes.
RESUMO
RESUMO O reconhecimento precoce da Doença Cerebrovascular (DCV) pode permitir o controle de fatores de risco e a prevenção de demência. Contudo, critérios operacionais em seus estágios sintomáticos não-demenciais apresentam problemas, já que critérios atuais requerem a presença de extensa doença isquêmica subcortical. OBJETIVO Identificar o perfil de neuroimagem do Comprometimento Cognitivo Leve Vascular (CCLV), o impacto destes aspectos sobre a cognição e os testes neuropsicológicos que distinguem CCLV de outros grupos. MÉTODOS Foram realizadas buscas no Scopus, ISI e PsycINFO, usando a estratégia "vascular mild cognitive impairment" OR "vascular cognitive impairment no dementia" OR "vascular cognitive impairment not demented" OR "subcortical mild cognitive impairment". RESULTADOS De 249 artigos, 20 foram selecionados. 10 destes incluíram apenas pacientes com hiperintensidades de substância branca (HSB) graves, enquanto 10 outros admitiram pacientes com HSB moderadas-a-graves. Ambos os grupos apresentaram desempenho pobre em tarefas de Função Executiva (FE) em comparação com controles normais e outras categorias diagnósticas. Dentre os testes de FE, aqueles que avaliam FE "complexas" diferiram consistentemente CCLV de outros grupos, independentemente da gravidade de HSB. Sujeitos com CCLV e HSB graves ou moderadas-a-graves apresentaram dificuldades cognitivas quando comparados aos demais grupos. Testes que avaliam FE "complexa" foram os mais úteis na diferenciação destes pacientes dos outros grupos. CONCLUSÃO A ocorrência de VaMCI pode estar associada à presença de HSB moderadas; a detecção precoce do dano vascular permitiria a adoção de medidas terapêuticas com tamanhos de efeito significativos.
Key words
Full text:
1
Index:
LILACS
Main subject:
Dementia, Vascular
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Cerebral Infarction
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Cerebrovascular Disorders
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Diagnostic Techniques, Neurological
Type of study:
Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Dement. neuropsychol
Journal subject:
NEUROCIENCIAS
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NEUROLOGIA
/
PSICOLOGIA
/
PSIQUIATRIA
Year:
2015
Type:
Article
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Project document