Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population
Arch. Clin. Psychiatry (Impr.)
; 43(2): 27-30, Mar.-Apr. 2016. tab, ilus
Article
in En
| LILACS
| ID: lil-782109
Responsible library:
BR1.1
ABSTRACT
Abstract Background Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.
Key words
Full text:
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Index:
LILACS
Main subject:
Polymorphism, Genetic
/
Population
/
Depression
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Arch. Clin. Psychiatry (Impr.)
Journal subject:
PSIQUIATRIA
Year:
2016
Type:
Article