Infección por virus herpes humano 6 en un paciente inmunocompetente con síndrome DRESS secundario a carbamazepina / Human herpes virus 6 infection in an inmunocompetent patient with carbamazepine-induced DRESS syndrome
Rev. chil. infectol
; 33(3): 340-345, jun. 2016. ilus, mapas
Article
in Es
| LILACS
| ID: lil-791029
Responsible library:
CL1.1
RESUMEN
El síndrome DRESS (drug reaction with eosinophilia and systemic symptoms) constituye una reacción adversa a fármacos, potencialmente mortal, caracterizada por una erupción cutánea polimorfa asociada a fiebre, linfadeno-patías y compromiso multiorgánico con eosinofilia. Presentamos el caso clínico de un hombre inmunocompetente con un síndrome DRESS secundario a carbamazepina que cursó concomitantemente con una meningoencefalitis por virus herpes humano 6 (VHH-6). El rol patogénico del VHH-6 en el síndrome DRESS sigue siendo controversial; sin embargo, dada la importancia diagnóstica y eventualmente pronóstica de la infección por VHH-6, su tamizaje sería recomendable dentro del estudio de estos pacientes.
ABSTRACT
DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is an adverse life-threatening drug reaction characterized by a polymorphous rash associated with fever, lymphadenopathy and multiorgan involvement with eosinophilia. We present the case of an immunocompetent man with DRESS syndrome secondary to carbamazepine, that developed concomitantly meningoencephalitis caused by human herpes virus 6 (HHV-6), and a review of literature. The pathogenic role of HHV-6 in DRESS syndrome remains controversial. Given the diagnostic and possibly prognostic significance of HHV-6, the screening seems to be a good measure to use in the clinical management of these patients.
Key words
Full text:
1
Index:
LILACS
Main subject:
Carbamazepine
/
Herpesvirus 6, Human
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Drug Hypersensitivity Syndrome
/
Immunocompetence
/
Meningoencephalitis
/
Anticonvulsants
Type of study:
Prognostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
Es
Journal:
Rev. chil. infectol
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2016
Type:
Article