Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; Braz. J. Psychiatry (São Paulo, 1999, Impr.);38(3): 247-254, July-Sept. 2016. tab, graf
Article
in En
| LILACS
| ID: lil-792752
Responsible library:
BR1.1
ABSTRACT
Objective:
To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data.Methods:
We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted.Results:
Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities.Conclusion:
Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults.Key words
Full text:
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Index:
LILACS
Main subject:
Randomized Controlled Trials as Topic
/
Depressive Disorder, Major
/
Exercise Therapy
Type of study:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Aged
/
Aged80
/
Female
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Humans
/
Male
Language:
En
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
/
Brazilian Journal of Psychiatry (São Paulo. 1999. Impresso)
/
Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
/
Rev Bras Psiquiatr
/
Revista Brasileira de Psiquiatria
Journal subject:
PSIQUIATRIA
Year:
2016
Type:
Article