Association study in Alzheimers disease of single nucleotide polymorphisms implicated with coffee consumption
Arch. Clin. Psychiatry (Impr.)
; Arch. Clin. Psychiatry (Impr.);42(3): 69-73, May-Jun/2015. ilus, tab, graf
Article
in En
| LILACS
| ID: lil-797117
Responsible library:
BR66.1
ABSTRACT
There is evidence from animal and in vitro models of the protective effects of caffeine in Alzheimers disease. The suggested mechanisms through which caffeine may protect neurons against Alzheimers disease pathology include the facilitation of beta-amyloid clearance, upregulation of cholinergic transmission, and increased neuronal plasticity and survival. Epidemiological studies support that Alzheimers disease patients consume smaller amounts of coffee beverages throughout their lives as compared to age-matched cognitively healthy individuals. Objective:
The aim of the present study was to determine whether the negative association between Alzheimers disease and coffee consumption may be influenced by a common genetic predisposition, given the fact that the pattern of coffee consumption is determined by both environmental and genetic factors.Method:
We conducted an in silico search addressing the association between genetic polymorphisms related to coffee consumption and the diagnosis of Alzheimers disease. We further investigated the interactions between genes located in regions bearing these polymorphisms.Results:
Our analysis revealed no evidence for a genetic association (nor interaction between related proteins) involving coffee consumption and Alzheimers disease.Discussion:
The negative association between Alzheimers disease and coffee consumption suggested by epidemiological studies is most likely due to environmental factors that are not necessarily regulated by genetic background...Key words
Full text:
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Index:
LILACS
Main subject:
Polymorphism, Genetic
/
Caffeine
/
Alzheimer Disease
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Arch. Clin. Psychiatry (Impr.)
/
Arch. Clin. Psychiatry (Online)
/
Archives of Clinical Psychiatry (Impresso)
/
Psiquiatria clínica
/
Rev. psiquiatr. clín. (São Paulo)
/
Revista de Psiquiatria Clínica
Journal subject:
PSIQUIATRIA
Year:
2015
Type:
Article