Hypertonic saline reverses bupivacaine-induced depression of rabbit Purkinje fiber depolarization Vmax
Braz. j. med. biol. res
;
22(11): 1393-6, 1989. ilus
Article
in English
| LILACS
| ID: lil-83144
ABSTRACT
The present study describes the effect of a hypertonic increase in sodium chloride concentration on electrophysiological parameters. Membrane depolarization was recorded from rabbit Purkinje fibers superfused with warm, aerated Tyrode solution. An amount of 5% NaCl above that in normal Tyrode solution (HyNaCl, 344 mOsm) was added to the bathing medium for 30 min, significantly increasing the maximal rate of depolarization (Vmax + 15% vs - 7% for control), with minor effects on other parameters. When bupivacaine was superfused over the preparation for 30 min either in normal Tyrode or in HyNaCl, Vmax was significantly deveased (33% and 15%, respectively). HyNaCl protected the cardiac tissues from the depressive effect of 05micron/ml bupivacaine. We suggest that the infusion of hypertonic saline in intact animals may prove effective in preventing or reversing the cardiodepressant effect of bupivacaine
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Index:
LILACS (Americas)
Main subject:
Purkinje Fibers
/
Bupivacaine
/
Hypertonic Solutions
/
Isotonic Solutions
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
/
Congress and conference
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