Hyperosmotic sodium chloride partially blocks the effects induced by Bothrops jararaca venom on vascular permeability and hemorrhage in the rat

ABSTRACT

The effect of the administration of hyperosmotic NaCl (2 ml, 7.8% NaCl, iv) on hemorrhage and vascular permeability changes induced by Bothrops jararaca venom in rats was determined 30 min after venom injection. This treatment given immediately after subcutaneous venom injection significantly reduced the hemorrhagic manifestations by 33%. The increase in vascular permeability was significantly reduced when the animals were pretreated with hyperosmotic saline or mannitol 15 min before receiving the venom (26% and 20%, respectively). However, when animals were treated immediately after venom injection, only the hyperosmotic NaCl solution significantly reduced vascular permeability (32%). Isotonic NaCl treatment had no effect on hemorrhagic lesions or vascular permeability