Administration of the plasticizer di (2-ethylhexyl) phthalate alters glycoconjugate profile.
Indian J Physiol Pharmacol
; 1995 Jul; 39(3): 252-4
Article
in En
| IMSEAR
| ID: sea-107247
ABSTRACT
This study was undertaken to evaluate the level of glycoproteins and sialic acid in rats fed di (2-ethylhexyl)-phthalate (DEHP) in the diet for 24 weeks. Protein-bound hexose, hexosamine and sialic acid were increased in plasma and liver of rats treated with DEHP, whereas the erythrocyte membrane showed a reduction following DEHP administration. Evaluation of glycoproteins is a useful indicator of the carcinogenic process. It is suggested that profound alterations in membrane components observed in the present study may be related to the carcinogenic potential of DEHP.
Full text:
1
Index:
IMSEAR
Main subject:
Plasticizers
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Protein Binding
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Rats
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Sialic Acids
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Male
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Glycoproteins
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Rats, Wistar
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Diethylhexyl Phthalate
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Erythrocyte Membrane
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Hexosamines
Language:
En
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article