Action of some amides of substituted ethylenediamines on central nervous system.
Indian J Physiol Pharmacol
;
1987 Apr-Jun; 31(2): 125-9
Article
in English
| IMSEAR
| ID: sea-108515
ABSTRACT
Five of the substituted ethylenediamine amides (LMG I to V) were tested for various CNS attributes and for acute toxicity (24 hr mortality). All compounds were potent analgesics in various animal tests, LMG V being most potent. All reduced spontaneous activity of mice and potentiated ether anaesthesia. However, CAR was not altered and anti-MES were not pronounced in rats. Compounds appear to have a wide safety margin considering ED50 and LD50 in mice.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Reflex
/
Female
/
Male
/
Central Nervous System
/
Ethylenediamines
/
Amides
/
Analgesics
/
Lethal Dose 50
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1987
Type:
Article
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