Investigation into the possible mechanisms involved in altered digoxin levels in diabetic patients.
Indian J Physiol Pharmacol
;
1996 Jan; 40(1): 65-9
Article
in English
| IMSEAR
| ID: sea-108571
ABSTRACT
The present study was undertaken to investigate the possible factors which may contribute to the altered digoxin levels in diabetic patients. The digoxin levels were found to be significantly higher in diabetics (1.74 +/- 0.09 ng/ml) as compared to non-diabetics (0.76 +/- 0.07 ng /ml). There was a positive correlation between digoxin levels and glycosylated haemoglobin levels. All diabetic patients had serum creatinine, urea and potassium levels within normal limits. However, serum TSH levels were found to be significantly higher in diabetics as compared to controls. Serum tri-iodo-1-thyronine (T3) levels were found to be lower in diabetics as compared to non-diabetics. Our data suggests that diabetes-mellitus causes alteration of digoxin levels. One of the causes of this increase in digoxin levels may be a tendency towards mild hypothyroidism associated with diabetes mellitus.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thyroid Function Tests
/
Thyroid Hormones
/
Blood Glucose
/
Aged
/
Female
/
Humans
/
Male
/
Glycated Hemoglobin
/
Cardiotonic Agents
/
Cholesterol
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1996
Type:
Article
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