Effect of nimodipine on male reproductive functions in rats.
Indian J Physiol Pharmacol
;
2000 Oct; 44(4): 449-55
Article
in English
| IMSEAR
| ID: sea-108734
ABSTRACT
Nimodipine, a dihydropyridine calcium channel blocker, was administered orally using two different doses (40 mg and 60 mg/kg/day) to rats. Both short term (2 weeks) and long term (6 weeks) effects of the drug were observed. The drug administration resulted in a marked decrease in sperm density, sperm motility and acrozomal reaction. Zona-pellucida penetration by the sperm obtained from drug-treated animals was significantly lower when compared with sperm from normal animals. Nimodipine stimulated Ca2+ ATPase activity in isolated plasma membrane of rate spermatozoa. In conclusion, short term and long term administration of nimodipine has deleterious effect on male reproductive functions in rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Reproduction
/
Sperm Count
/
Sperm Motility
/
Zona Pellucida
/
Female
/
Male
/
Calcium Channel Blockers
/
Nimodipine
/
Calcium-Transporting ATPases
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2000
Type:
Article
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