Redifferentiation of human hepatoma cells (SMMC-7721) induced by two new highly oxygenated bisabolane-type sesquiterpenes.
J Biosci
; 2008 Dec; 33(5): 723-30
Article
in En
| IMSEAR
| ID: sea-111047
ABSTRACT
Bisabolane-type sesquiterpenes are a class of biologically active compounds that has antitumour,antifungal, antibacterial,antioxidant and antivenom properties.We investigated the effect of two new highly oxygenated bisabolane-type sesquiterpenes (HOBS)isolated from Cremanthodium discoideum (C.discoideum) on tumour cells. Our results showed that HOBS induced morphological differentiation and reduced microvilli formation on the cell surface in SMMC-7721 cells.Flow cytometry analysis demonstrated that HOBS could induce cell-cycle arrest in the G1 phase. Moreover,HOBS was able to increase tyrosine-alpha ketoglutarate transaminase activity,decrease alpha- foetoprotein level and gamma-glutamyl transferase activity. In addition,we found that HOBS inhibited the anchorage- independent growth of SMMC-7721 cells in a dose-dependent manner.Taken together,all the above observations indicate that HOBS might be able to normalize malignant SMMC-7721 cells by inhibiting cell proliferation and inducing redifferentiation.
Full text:
1
Index:
IMSEAR
Main subject:
Sesquiterpenes
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Structure-Activity Relationship
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Humans
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Molecular Structure
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Alpha-Fetoproteins
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Cell Cycle
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Cell Differentiation
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Carcinoma, Hepatocellular
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Asteraceae
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Hepatocytes
Language:
En
Journal:
J Biosci
Year:
2008
Type:
Article