Epilepsy with focal cerebral calcification: role of magnetization transfer MR imaging.
Neurol India
;
2004 Jun; 52(2): 197-9
Article
in English
| IMSEAR
| ID: sea-120735
ABSTRACT
BACKGROUND:
Some patients with focal cerebral calcification (FCC) have no seizure or a benign course of epilepsy, whilst others with a similar lesion have uncontrolled epilepsy.AIMS:
To look for perilesional hyperintensity, presumed to be indicative of gliosis, around FCC on magnetization transfer (MT) MRI and to correlate seizure outcome with its presence. SETTING ANDDESIGN:
Case control study. MATERIAL ANDMETHODS:
Fifty-one patients with epilepsy and 30 controls with single calcified cerebral lesion on CT were studied. Clinical and treatment details were noted. EEG and T1, T2, MT and contrast enhanced MRI were done. STATISTICAL ANALYSIS USED Student's t test.RESULTS:
On MT MRI, perilesional gliosis was seen around the focal calcified lesion in 17 (33.3%) patients. None of the controls had perilesional gliosis. The mean monthly seizure frequency was significantly higher in the 17 patients having perilesional gliosis (2.63+1.15) as compared to the 34 patients without it (0.59+0.63; P= 0.0014). Perilesional gliosis was seen in 8 out of 11 (72.7%) patients who were on 2 AEDs and in all 5 (100%) patients who were on 3 or more AEDs. It was present only in 4 (11.4%) out of 35 patients who were on one AED.CONCLUSION:
Gliosis around a cerebral calcified lesion as seen on T1 weighted MT MRI indicates poor seizure control.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Brain Diseases
/
Female
/
Humans
/
Male
/
Calcinosis
/
Magnetic Resonance Imaging
/
Case-Control Studies
/
Child
/
Adolescent
/
Adult
Type of study:
Observational study
/
Risk factors
Language:
English
Journal:
Neurol India
Year:
2004
Type:
Article
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